Understanding ketones and their role in epilepsy

A ketogenic diet may be an effective low-carbohydrate diet to treat epilepsy, especially in children with refractory epilepsy. This dietary approach forces the body to use fat as its primary energy source instead of carbohydrates, leading to the production of ketones—a metabolic state called ketosis.

Managing this diet with precisely calculated calorie and nutrient intake is essential, as improper adherence can lead to nutrient deficiencies. The ketones produced during ketosis help reduce seizure frequency and severity, addressing a key risk factor in epilepsy management.

Why start a medical ketogenic diet?

Studies have shown that a key component in managing intractable or refractory epilepsy is achieving a state of ketosis. This occurs naturally when the human body begins to fast and the brain gets its energy from fat. These fats produce ketones. In a normal diet, the main source of energy is carbohydrates.

The effects of a low-carbohydrate diet as a treatment for epilepsy are supported by a meta-analysis of randomized controlled trials showing a significant seizure reduction. This diet may help by providing foods which are high in fat and very low in carbohydrates, shifting the metabolism into a state called ketosis. Ketogenic therapy works by changing the way that the brain’s electrical impulses work, thus avoiding the symptoms commonly associated with intractable or refractory epilepsy.

However, it isn’t as simple as it sounds. A ketogenic ratio is precisely calculated and must be strictly followed. Managing the diet requires a careful calorie and nutrient balance to avoid nutrient deficiencies. A dietitian or doctor will calculate the exact amount of fat to carbohydrate and protein needed to reach a state of ketosis.

At least 50% of children with epilepsy that follow a supervised medical ketogenic diet show a 50% or greater reduction of symptoms. (Epilepsy Ontario)

Our KetoCal® products

KetoCal is indicated for the dietary management of refractory epilepsy and is intended for use under medical supervision. Talk to your healthcare provider to determine if KetoCal is right for you.

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